Functional Characterization of Three Novel Tissue-specific Anion Exchangers SLC26A7, -A8, and -A9
نویسندگان
چکیده
منابع مشابه
Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9.
A second distinct family of anion exchangers, SLC26, in addition to the classical SLC4 (or anion exchanger) family, has recently been delineated. Particular interest in this gene family is stimulated by the fact that the SLC26A2, SLC26A3, and SLC26A4 genes have been recognized as the disease genes mutated in diastrophic dysplasia, congenital chloride diarrhea, and Pendred syndrome, respectively...
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The secretin-stimulated human pancreatic duct secretes HCO(3)(-)-rich fluid essential for normal digestion. Optimal stimulation of pancreatic HCO(3)(-) secretion likely requires coupled activities of the cystic fibrosis transmembrane regulator (CFTR) anion channel and apical SLC26 Cl(-)/HCO(3)(-) exchangers. However, whereas stimulated human and guinea pig pancreatic ducts secrete ∼140 mM HCO(3...
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An economic comparison of reverse osmosis and ion exchange in Europe. In: Greig JA (ed.) Ion Exchange Development and Applications, pp. 58}66. Cambridge: Royal Society of Chemistry. Nolan J and Irving J (1984) The effect on the capacity of strong base anion exchange resins of the ratio of chloride to sulphate in the feed water. In: Naden D and Streat M (eds) Ion Exchange Technology, pp. 160}168...
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Previous studies have indicated that a major fraction of the filtered Cl(-) is reabsorbed via apical membrane Cl(-)/base exchange in the proximal tubule. Recent studies in Slc26a6 null mice have suggested that this transporter mediates only a portion of proximal tubule Cl(-)/base exchange, raising the possibility that one or more unidentified apical membrane transporters may additionally contri...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m111802200